DIHS/DRESS with remarkable eosinophilic pneumonia caused by zonisamide.
نویسندگان
چکیده
Fever ≥38.5°C No/U Yes 0 Enlarged lymph nodes No/U Yes 0 Eosinophils No/U 0.7–1.499 × 109l–1 ≥ 1.5× 109l–1 1 Atypical lymphocytes No/U Yes 1 Skin involvement 2 Skin rash extent (% body surface area) No/U > 50% Skin rash suggesting DRESS No/U Yes Biopsy suggesting DRESS No Yes/U Organ involvementa 2 Liver No/U Yes Yes Kidney No/U Yes No/U Lung No/U Yes Yes Muscle/heart No/U Yes No/U Pancreas No/U Yes No/U Other organ No/U Yes No/U Resolution ≥15 days No/U Yes 0 Evaluation of other potential causes Antinuclear antibody Blood culture Serology for HAV/HVB/HCV Chlamydia/mycoplasma If non positive and ≥ 3 of above negative Yes 1 Total score 7
منابع مشابه
Acute kidney injury caused by zonisamide-induced hypersensitivity syndrome.
Drug rash with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DIHS), is a severe adverse drug reaction affecting multiple organs caused by drug treatment. The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfu...
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Results Twenty-three cases of SCAR were identified: 12 DRESS/ DIHS, 1 overlap DRESS/AGEP and 10 SJS/TEN. Sixteen patients (70%) were female, the median age was 41 years (IQR=26-50). The aromatic anticonvulsivants were implicated in the etiology in 73% of cases, followed by antibiotics (30%). All patients with DRESS/DIHS exhibited cutaneous, systemic and laboratory characteristic changes of this...
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BACKGROUND Drug-induced hypersensitivity syndrome/drug rash with eosinophilia with systemic symptoms (DIHS/DRESS) is a severe drug eruption accompanied by multiorgan disorders. Several unique aspects of DIHS/DRESS, including herpesvirus reactivation, liver dysfunction and hypogammaglobulinaemia, have similarities to graft-versus-host disease (GVHD). AIM In this study, we focused on the dynami...
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Immune reconstitution inflammatory syndrome (IRIS) is originally described in association with antiretroviral therapy (ART) for HIV infected patients. IRIS consists of a broad spectrum of inflammatory diseases, such as infectious inflammatory, neoplastic, and autoimmune diseases, that present after starting an effective ART, leading to CD4+ cells increase and plasma HIV-RNA reduction. IRIS refl...
متن کاملDrug reaction with eosinophilia and systemic symptoms: A drug-induced hypersensitivity syndrome with variable clinical features
Drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS) involves a unique and severe adverse drug reaction. Patients present with fever, rash, lymphadenopathy, hematological abnormalities, systemic illness, and may suffer from prolonged courses. Although the precise pathogenesis of DRESS/DIHS is not fully understood, it is widely considered...
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ورودعنوان ژورنال:
- Acta dermato-venereologica
دوره 95 2 شماره
صفحات -
تاریخ انتشار 2015